In 1910, the German bacteriologist Paul Ehrlich made a groundbreaking discovery and patented arsphenamine, a chemical compound derived from arsenic that proved effective against syphilis and was marketed for two decades under the trade name ‘Salvarsan’.
Ehrlich, who had already been awarded a Nobel Prize for his vaccine research, had a profound impact on 20th-century pharmacology with his concept of the “magic bullet”:a pharmacological compound that specifically targets a particular pathogen without harming the host’s body.
‘Salvarsan’ was the first successful drug based on the “magic bullet” hypothesis and saved millions of lives in Europe until the introduction of penicillin, discovered by Alexander Fleming two decades later. Penicillin proved to be more effective than ‘Salvarsan’ for treating syphilis and other infectious diseases. However, the echo of Ehrlich’s discovery and the “magic bullet” concept continues to resonate, albeit with diminishing influence.Read more